mRNA COVID shots form spike protein in heart cells | Eastern NC Now

Pfizer-vaccinated cells displayed stronger, sustained contractions (1B) due to increased protein kinase A (PKA) activity. PKA levels are linked to heart performance; the higher the PKA level, the stronger the heart contractions.

Moderna-vaccinated cells developed irregular heart contractions and disrupted calcium regulation. The authors attributed the change in cell activity to disturbances in RyR2 receptors. These receptors play a key role in coordinating heart contractions using calcium.

Some of the heart muscles administered Moderna vaccines developed irregular and peristaltic contractions (1C and 1D), whereas others had irregular and arrhythmic contractions (1E and 1F).

Spike proteins were also detected within 48 hours in the cell culture of human cells.

The authors concluded that at the cellular level, the effects of the COVID-19 vaccines seemed to align closer with cardiomyopathy than with myocarditis. Cardiomyopathy is a condition where heart muscles become both structurally and functionally abnormal in the absence of other heart diseases. This differs from myocarditis and pericarditis, which occur when heart muscles become inflamed and damaged.

A diagnosis of myocarditis and pericarditis indicates inflammation and damage to heart muscle cells, yet doctors may fail to find signs of damage and inflammation in blood and imaging tests.

"The present preclinical cardiac safety data point to the need for a reassessment of the risk–benefit ratio of RNA-based SARS-Cov-2 vaccines, given indication of their cardiotoxicity," the authors wrote.

The heart abnormalities exhibited in the cells, likely caused by disruption to RyR2 and increased PKA protein levels, "are risk factors for sudden cardiac death, ventricular tachyarrhythmias, and contractile dysfunction," they added.

If the two vaccines provoked a similar response, that might suggest that most of the adverse events were driven by the spike proteins produced by the mRNA instructions. However, Moderna and Pfizer vaccines distinctively inducing different cardiac abnormalities may suggest toxicity of the mRNA itself.

Overall, vaccinated people saw a shift in metabolism, suggesting abnormal heart function. Typically, heart muscle cells rely on fat for fuel, but the hearts of vaccinated people showed a more substantial reliance on 18 fluorodeoxyglucose, a type of glucose.